Run winkill to Disable the Windows Keys
The Windows key pulls up the Start menu, and when pressed with other keys, it can trigger other Windows-related shortcuts. If you find yourself accidentally doing this while gaming, watching videos, etc., you can avoid this distraction by simply disabling the key. One way to do this is by running a small, portable program to disable Windows keys instantly. Enabling them again is as simple as pressing one button, meaning that you can switch between enabled and disabled mode at any time (no reboot required, like the other methods below).
Pick Which Windows Key to Disable With SharpKeys
Another free program gets the job done, as well. Go this route if you want control over which key gets disabled. If you need the key to be usable again, open SharpKeys, select the key from the list, choose Delete at the bottom, and then complete the same last two steps from above.
Edit the Registry to Disable the Windows Key
Not interested in having a program do it for you? You can make the change yourself manually by creating a new entry in the registry and giving it a very specific value. To undo this, complete Step 3 and remove Scancode Map by right-clicking it and choosing Delete. Alternatively, rename it—anything will do, like Scancode Map OLD—to turn on the keys. Renaming it makes it easy to return to the first name later if you want to block them again.